Friday, February 15, 2019

Estrogen Hormone – In Diabetes Control ???





Estrogen is a hormone which is mainly associated with females. Men also produces Estrogen, but Higher levels of estrogen is produced by females. Although it is present in smaller amounts, yet it plays prominent role maintaining health.

Gender related differences is shown by Type 2 diabetes. It was found that There is reduced incidence of occurring of type 2 diabetes in premenopausal women.

Estrogen acts by improving insulin sensitivity and by suppressing Gluconeogenesis. Estrogen role in controlling glucose homeostasis had given profound of understand diabetes, obesity and interventions of potential diet.

Lowered Insulin resistance and plasma glucose levels have observed in clinical trails of estrogen Replacement therapy in postmenopausal women. This is because deficiency of estrogen or impaired estrogen signaling is found to be associated with fault in regulation of metabolic homeostasis and insulin resistance which results in the development of type 2 diabetes.

As we said premenopausal women are less prone to incidence of type 2 diabetes than with age -equivalent men, but after menopause this advantage in women will disappear with glucose homeostasis as a result of reduced estrogen levels in the body.

Estrogen with potential effect of reducing the occurring of type 2 diabetes causes risk of breast cancer or stroke as side effects of estrogen therapy. But development of targeted estrogens will mimic the therapeutic benefits without any side effects.

Estrogen reduces the risk of developing type 2 diabetes via transcription factor FOXO-1, which increases the insulin resistance and Suppresses Gluconeogenesis.

FOXO-1 plays important role in regulating glucose production via insulin signaling and it is a key component of insulin signaling pathway with regulates cellular growth, differentiation and metabolism.

Hepatic Glucose production is suppressed by Estrogen through activation of estrogen receptor signaling which is independent of receptor substrates Irs1 and Irs2 of insulin which had given a important mechanism for estrogen in regulation of glucose homeostasis.

By the development of novel selective ligands through direct target estrogen receptors prevent type 2 diabetes, cardiovascular disease and Obesity with rising abnormal sexual characteristics and breast cancer.

Fundamental understand of dietary interventions can play a crucial role in controlling weight gain, glucose levels and related harmful diseases.

















Friday, February 8, 2019

Diabetes in Healthcare: What A mistake !!!!!


               
 


          


Diabetes is holding total populace and however the reason can be inherited or procured as a result of way of life or some other reason, the issue is prominent. Around 162 million population, which is over 7.1% of the grown-up populace have diabetes. The normal period of beginning is 42.5 years. About 10 million people kick the bucket because of diabetes consistently. The quantity of individuals being determined to have prediabetes or Type 2 Diabetes is expanding step by step.

It is fundamental to think about real regular errors in diabetes the board and how to keep away from them. It can tedious simply learning the essentials. This Blog include a portion of the normal oversights diabetics make couple of answers for help you gain control of your glucose!

IRREGULAR EATING HABITS
Nutrition in diabetes plays important role. Poor dietary patterns are one of the impediments in keeping up an ideal sugar level. And by unpredictable dietary pattern I mean not having the capacity to keep up dinner timing and calorie consumption, you realize your treatment need a specific measure of calorie admission that if not kept up can spike your sugar level. This probably won't be your blame, yet it is basic to monitor sound, maintaining a strategic distance from void carbs and following the eating routine diagram recommended by the dietician.

The most ideal route for diabetics to eat soundly and utilize the monetary allowance on shopping carefully by just purchasing things that are endorsed that is entire flour, oats (dals), vegetables, lean meat etc. Point being, just purchase those things that are basic for your diet. Steer clear from the things that are enticing yet have void carbs.

THINKING DIABETES CAN BE “CURED”
Constructive reasoning is the most ideal method for keeping an arrangement between one's psyche and body. It additionally moves an individual to continue sticking to the eating routine designs. Along these lines, if your specialist tells your hemoglobin A1C was flawlessly typical. This implies your greater part of blood sugars has had been in the typical range in the course of the most recent three months. There is no solution for diabetes right now. However, Type 2 diabetes is reversible and can be monitored with great administration.

Anyone with Type 2 diabetes or healthy should always have their blood sugar levels in mind all the time. Even if you are under control, the tendencies will always remain. Keep this in mind. Think Diabetes Can Be “Cured”.

NOT KEEPING LOG OF BLOOD SUGAR
The biggest mistake one makes in the management of the diabetes is not keeping the blood sugar log. This a disease that requires the proactive cooperation of both patients and the doctor. Your doctor needs to know a trend of blood sugars a few times a day in order to decide the best course of action.
The greatest slip-up one makes in the administration of the diabetes isn't keeping the glucose log. This an illness that requires the proactive collaboration of the two patients and the specialist. Your specialist has to know a pattern of blood sugars a couple of times each day so as to choose the best strategy.

On the off chance that you are appearing of "pre-diabetes" or Type 2 Diabetes, have your doc compose a remedy for a glucose screen and test strips. Test twice day by day the quantity of recommended occasions, keep the numbers in a log book. Along these lines your specialist can see patterns. Also, don't assume you can "make" the numbers either. Your Hemoglobin A1C will tell your specialist a normal of what your blood sugars were in the course of the most recent 3 months.

NOT DOING EXERCISE REGULARLY
So your eating regimen is set up and your drug plan is all elegantly composed, being followed. You are additionally keeping up a glucose log as well yet these are worthless in the event that you are not doing exercise regularly. Yes, practice likewise help to bring down the glucose level and make you feel better. It's beneficial for you blood course, veins wear out from expanded glucose.

Calendar time for you day by day and get some activity. Be tireless while checking your glucose when work out. - Eat a light bite to keep your glucose from going excessively low.

THINKING THAT ONLY FOOD IMPACTS THE BLOOD SUGAR
Starches, and to a lesser degree fat and protein, sway blood sugars. Yet, sustenance is only one of numerous variables. - Stress – regardless of whether it is brought about by torment, a battle with a friend or family member, or serious exercise – expands blood sugars. - Sleep designs impact insulin affectability for the duration of the day. Not getting enough rest can make you more insulin safe and lead to higher blood sugars. - Hormonal changes can cause your glucose to rise and fall.




Friday, February 1, 2019

Stem Cells therapy – A Closer Look at Type 1 & 2 Diabetes

           
                                     






    

              Stem Cells therapy – A Closer Look at Type 1 & 2 Diabetes



Diabetes has turned into a Major endemic issue the world over with an extravagant sticker price. Its rate is on the ascent, fueled by our computerized way of life and the developing endemic of weight. The International Diabetes Federation (IDF) assesses that in 2015, there were 415 million diabetic grown-ups matured 20– 79 years around the world, including 193 million undiscovered subjects. Another 318 million grown-ups are assessed to have pre-diabetes or hindered glucose tolerance and insulin obstruction. The expense of diabetes care is evaluated at $673 billion every year. The American Diabetes Association (ADA) appraises that generally 9.3% of the American populace is diabetic with about 2– 3-times the same number of perhaps having pre-diabetes.

The pancreatic islets of Langerhans are modest bunches of cells dissipated all through the pancreas comprising of a few gatherings of specific cells, including insulin-producing beta cells. The pathology of Type 2 diabetes mellitus (T2DM) joins an inflammatory– immune system microenvironment influencing the insulin-generation units. More critically, dysfunction of the insulin receptors follows, to peripheral insulin resistance. Another part of the pathobiology is boundless microvascular disease, which prompts a considerable lot of the clinical indications and complications going with T2DM, including limb ischemia and ulcers, retinal harm, impotence, neuropathies, nephropathies, and cardiovascular and cerebral-vascular disease.

stem cells are the mother cells of the body which can separate into the required kinds of cells after channelizing through appropriate technique. Research has obviously proposed that once inside the body, they can advance the recovery of lost pancreatic cells, also re-outline immune system. The treatment consoles the safety of the patient.

The stem cell therapy in diabetes approach chiefly centers around conveying the adequate number of Adult Autologous Stem Cells which will go into numerous areas of the damaged parts.
Stem cells are being utilized to make new cell culture and animal models of diabetes that better reflect what occurs in a human. As one precedent, skin cells from an individual with diabetes can be reinvented into prompted pluripotent stem (iPS) cells that can possibly make any cell type in the body, including beta cells, just as the safe cells that attack and destroy beta cells in type 1 diabetes. The cell types associated with diabetes – the beta and immune cells – are being contemplated in the way of life dish, just as transplanted into lab animals.

This empowers scientists to follow the disease from the soonest stages, before the moment that diabetes is typically gotten in a patient. This gives us better comprehend what occurs, what the hereditary causes might be and to recognize contrasts and likenesses between various patients. Furnished with this data, scientists search for approaches to analyze individuals prior, keep their diabetes from deteriorating, and to all the more viably treat the infection.

Developing and testing a genuinely powerful undifferentiated cell based treatment for diabetes will take years. Specialists are seeing approaches to reestablish the quantity of utilitarian beta cells in patients with diabetes, seeking after both the substitution of lost beta cells and the protection of beta cells from further harm.

The initial segment of this is to create—or recover—cells that sense glucose and produce insulin that might be utilized to supplant the beta cells lost as both kind 1 and 2 diabetes progresses.

A few unique methodologies are being utilized, including:

Making beta cells from embryonic stem cells or iPS cells. Embryonic undifferentiated cells and iPS cells can be developed in substantial number in the lab and can possibly be urged into turning into any cell type in the body, including glucose sensing, insulin-protection beta cells. Late jumps forward in these innovations make this a promising road for creating expansive quantities of substitution beta cells.

Generating beta cells to make a lot more duplicates of themselves. Beta cells can do this in the pancreas, however generally very gradually and slowly as we get more seasoned. Scientists are searching for medications that may improve this self-recharging as a conceivable treatment for individuals with type 2 or beginning time type 1 diabetes.

Key to these methodologies is getting beta cells into a place in the body where they can work and protect them from what was harming them in any case. This incorporates transplantation into parts of the body where the substitution cells are less inclined to be assaulted by the safe framework or situation of the cells into defensive cases. Such cases are permeable and would permit little atoms, for example, glucose and insulin to go through while protecting the beta cells from the cells of the immune system.

For type 1 diabetes, there are various trial approaches being taken to control the insusceptible immune system attack on the beta cells. The vast majority of these are as yet being investigated in the lab. There are some clinical preliminaries in progress to test whether blood mesenchymal stem cells from the bone marrow may change or re-set the immune system so it never again assaults the beta cells. In any case, the components basic how this utilization of these cells would work are not surely knew, and further research is expected to set up whether any of these methodologies will demonstrate sheltered and successful.

Friday, January 18, 2019

Meditation -A remedy to Treat Diabetes?






                       


Numerous individuals swing to Meditation to assist the management of a particular medical issue, or example, Chronic pain or to get past a period of individual emergency. Others are essentially searching for a superior method to manage normal life stresses. 

You may wind up keen on attempting meditation for one of these reasons, however you might be concerned that you won't have time or drive to focus on rehearsing it consistently.  As you find out about meditation, don't be terrified off by supposing you should subscribe to an entirely different way of life. Meditation is simply one more great device you can use to help deal with your life and your diabetes.

As such, meditation isn't only a strategy drilled formally in a sanctuary or a congregation. Rather, it is a training that should be possible from numerous points of view and in numerous settings to encourage your psyche and body unwind. It can likewise enable you to grow progressively close to home understanding or, at times, enable you to build up your otherworldly life.

Mindfulness meditation is the act of working with concentrated attention to experience every minute completely. The purpose of this sort of meditation is to figure out how to carry on with your life all the more completely, not to sit in the lotus position for quite a long time multi day. It can likewise enable you to live with diabetes all the more completely. By building up a tolerant demeanor and more full consciousness of how your life and the administration of your diabetes communicate, you can figure out how to react keenly, as opposed to simply respond, while testing circumstances emerge.

Meditation for diabetes??

Medication will assist you with relaxing recently and give you some crisp apparatuses for managing pressure. Life stress is a major issue for us all. For the individuals who have diabetes, stretch introduces somewhere around two issues: The immediate impact of pressure raises blood glucose levels, and we are well on the way to take part in practices that are bad for our wellbeing when we are focused. We may will in general eat all the more high-starch nourishments or sit on the love seat and sit in front of the TV as opposed to working out. Whenever focused on, we will in general turn out to be not so much taught but rather more liberal.

Practicing meditation normally enables individuals to diminish their bodies' reactions to worry by bringing down circulatory rate, abating pulse, lessening oxygen allow, and changing the mind waves to a progressively loosened up state. Directing the pressure reaction is likewise liable to bring down blood glucose levels. Regular meditation constructs aptitudes in reacting carefully, implying that you will figure out how to set aside your opportunity to thoroughly consider your activities previously acting. As you practice reflection normally, you will start to see that the choices you make are progressively astute. The probability of getting for chips or dessert progresses toward becoming lower, and the likelihood of going for a walk increment. As it were, your capacity to deal with pressure will be fortified by great choices and you will be equipped for unwinding without taking part in negative practices.

Diabetes healthcare and meditation are the two practices that require order and responsibility. In any case, the adjustments are enormous for rehearsing them together. Diminished pressure, better diabetes control, bring down pulse, bring down blood glucose levels, more noteworthy mindfulness, better connections, enhanced concentration in different aspects of your life, and less discouragement and uneasiness are largely potential advantages of incorporating reflection in your everyday practice. Making meditation a normal piece of your diabetes the executives will upgrade both your frame of mind and control.

Meditation is a method for loosening up the psyche through centering and controlled breathing that decreases pressure, brings an increasingly tranquil perspective and calm an assortment of physical infirmities. Like controlled eating routine, and exercise, meditation, yoga and different types of care rehearses have been found to bring down glucose. Numerous individuals with diabetes discover meditation is a decent method to lessen pressure, bring down glucose levels. Research exhibited at an American Diabetes Association Conference demonstrated care meditation is gainful for individuals with diabetes. Medication is an incredible, successful supplement to medicinal treatment of diabetes and different diseases. It can help to keep the ailment, diminish the seriousness, and help to make a wellbeing elevating way of life to anticipate intensifying of the circumstance.

Friday, January 11, 2019

Ways to Improve Quality of life-style with Diabetes



                   


Adopting a solid way of lifestyle can help to avoid or delay the beginning of diabetes and is basic to manage diabetes. It's additionally basic to normalizing your basic health numbers, including weight, glucose, BP, and blood cholesterol.
People living with type 2 diabetes ought to understand that being overweight or fat makes it hard to deal with diabetes. It likewise builds the hazard for high blood cholesterol and hypertension, which are normal hazard factors for cardiovascular diseases- the main source of death among individuals with diabetes.




How to Improve Life Quality with diabetes:

Eating Healthy Food: This is pivotal when you have diabetes, since what you eat influences your glucose. No foods are entirely forbidden. Concentrate on eating as per the requirement of the body. Get a lot of vegetables, organic products, and entire grains. Pick nonfat dairy and lean meats. Limit sustenance’s that are high in sugar and fat. Keep in mind that carbohydrates transform into sugar, so watch your carb consumption. Attempt to keep it about the equivalent from dinner to supper. This is much increasingly vital on the off chance that you take insulin or medications to control your blood sugars.

Physical exercise: In case you're not dynamic presently, it's an ideal opportunity to begin. You don't need to go an exercise center and do broad physical activities. Simply walk, ride a bicycle, or play dynamic computer games. Your objective ought to be 30 minutes of movement that makes you sweat and inhale a little harder most days of the week. A functioning way of life encourages you control your diabetes by cutting down your glucose. It likewise brings down your odds of getting coronary illness. In addition, it can enable you to lose additional pounds and ease stress.

Get regular checkups: See your specialist at least like two times every year. Diabetes raises your chances of coronary illness. So take in your numbers: cholesterol, BP, and A1c (normal glucose levels over 3 months). Get a full eye test each year. Visit a foot specialist to check for issues like foot ulcers and nerve damage.

Stress Control: When you are stressed, your glucose levels go up. when you are anxious, you may not deal with your diabetes well. You may neglect to work out, eat right, or take your prescriptions. Discover approaches to ease stress - through profound breathing, yoga, or hobbies that loosen up you.

Avoid Smoking: Diabetes makes you to bound to have medical issues like coronary illness, eye malady, stroke, kidney sickness, vein ailment, nerve harm, and foot issues. On the off chance that you smoke, your possibility of getting these issues is significantly higher. Smoking likewise can make it harder to work out. Converse with your specialist about approaches to stop.

Control over Alcohol levels: It might be simpler to control your glucose in the case that you don't get excessively brew, wine, and alcohol. So on the off chance that you drink, don't try too hard. The American Diabetes Association says that ladies who drink liquor ought to have close to one beverage daily and men ought to have close to two. Liquor can make your glucose go excessively high or excessively low. Check your glucose before you drink and find a way to dodge low blood sugars. In the event that you use insulin or take drugs for your diabetes, eat when you're drinking. A few beverages - like wine coolers - might be higher in carbs, so consider when you count carbs.

Diabetes doesn't need to mean die early. Indeed, with proper management and diagnosis could really prompt a longer and healthier life.


Friday, October 12, 2018

Genetic regulation of metabolomic biomarkers: Paths to type 2 diabetes and cardiovascular diseases



The research has revealed eleven new genetic regions associated with the blood levels of the metabolites, including new loci affecting well-established risk markers for cardiovascular disease and potential biomarkers for type 2 diabetes.
In a study to the genetic variance of human metabolism, specialists have identified thirty one regions of the genome that were related with levels of circulating metabolites, i.e., small molecules that take part in different chemical reactions of human body. Many of the studied metabolites are biomarkers for cardiovascular disease or related disorders, accordingly the loci uncovered may provide valuable insight into the biological processes leading to common diseases.
Lab tests used in the clinic typically monitor one or few circulating metabolites. The researchers used a high throughput method called nuclear magnetic resonance that can measure more than hundred different metabolites in one assay. This provides a considerably more in-depth picture of circulating metabolic compounds.
The group assayed 117 detailed metabolic markers, including amino acids, lipids and lipoprotein subclasses, and conducted the largest genome-wide association analysis of this type, in terms of study sample size of 8330 individuals and 7.7 million genomic markers studied. They revealed, in total, 31 genetic regions related with the blood levels of the metabolites.
Among the discoveries were two new loci influencing serum cholesterol subclass measures, well-established risk markers for cardiovascular disease, and five new loci affecting levels of amino acids recently discovered to be potential biomarkers for type 2 diabetes. The found variants have significant effects on the metabolite levels, the effect sizes being in general considerably larger than the known common variants for complex disease have.
Additionally, using twin pair samples, the scientists indicated that the metabolite levels show a high degree of heritability. This result suggests that the studied metabolites are describing better the underlying biology than the routinely used lab tests. In this way, the examination provides further support for the use of detailed data on multitude of metabolites in genetic studies to provide novel biological insights and to help in elucidating the processes leading to common diseases.

Contact details:
Tiffany Hales
Program Manager | Diabetic 2018
Mail id: diabetes@mehealthevents.org

Friday, October 5, 2018

Evening preference, lack of sleep associated with higher BMI in people with prediabetes



Individuals with prediabetes, who go to bed later, eat meals later and are more active and alert later in the day. The individuals who have an evening preference have higher body mass indices compared with people with prediabetes who do things earlier in the day, or exhibit morning preference. According to study, the higher BMI among people with evening preference is related to their lack of sufficient sleep.
Prediabetes is where glucose levels are higher than typical however not yet high enough to be Type 2 diabetes. Without modifications to exercise and diet, patients with prediabetes have a very high risk of developing Type 2 diabetes.
Lack of sufficient sleep has been previously connected to an increased risk for various health conditions, including obesity and diabetes. Evening preference has likewise been connected to higher weight and higher risk for diabetes.
Diabetes is such a widespread disease with such an impact on quality of life, that identifying new lifestyle factors that might play into its development can help us advice patients with a beginning stage of the disease on things they can do to turn it around and prevent prediabetes from becoming full-blown diabetes.
Participants who scored high in morningness answered questions showing that they preferred to wake up earlier, have exercises prior, and felt more alert earlier in the day compared with individuals who scored high on eveningness. Sleep duration and timing were obtained using a questionnaire and the extent of social jet lag was assessed for each participant. Social jet lag reflects a shift in sleep timing among weekdays and weekends. Greater social jetlag has previously been shown to be associated with higher BMI in some populations. Average sleep duration was around seven hours per night.   
The scientists found that for participants younger than 60 years of age, more elevated levels of social jet lag were related with a higher BMI. Among participants older than 60 years old, those with more evening preference had higher BMIs and this impact was partly due to having insufficient sleep but not social jet lag. Evening preference was directly connected with higher BMI in this group. 
Timing and duration of sleep are potentially modifiable. Individuals can have more regular bedtimes and aim to have more sleep, which may help decrease body mass index and the potential development of diabetes in this high-risk group.

Contact details:
Tiffany Hales
Program Manager | Diabetic 2018
Mail id: diabetes@mehealthevents.org

Estrogen Hormone – In Diabetes Control ???

Estrogen is a hormone which is mainly associated with females. Men also produces Estrogen, but Higher levels of estrogen is pro...